Drunkenness is a terrible vice! It's a passion, a disease that enters the body through indulgence in desire, taking on the strength of a natural quality through habit.
A servant of Christ must guard himself not only from drunkenness but also from the habit of excessive wine consumption, which inflames the flesh and arouses bestial desires. "Do not be drunk with wine, for in that is debauchery" ( Eph. 5:18 ), said the apostle. Drinking wine in very small quantities is permissible, but those who cannot limit themselves to moderation would do better to abstain from it entirely.
Wine deprives a person of the ability to maintain sobriety of mind. When an ascetic is exposed to its effects, his enemies attack the weakened and darkened mind, and the mind is no longer able to fight them. Bound by the influence of wine, he is drawn into the abyss of sin! In an instant, the fruits of long-term asceticism are destroyed, because the Holy Spirit departs from those defiled by sin. This is why Saint Isaiah, the Egyptian hermit, said that those who love wine will never be granted spiritual gifts: for these gifts to remain in a person, they require constant purity, which is possible only with constant sobriety.
Source: https://azbyka.ru/otechnik/Ignatij_Brjanchaninov/simfonija-po-tvorenijam-svjatitelja-ignatija-brjanchaninova-tereshenko/230